Multivitamins May Lower Preeclampsia Risk

Results from a large study show that regular use of a multivitamin supplement in the months before and during pregnancy may reduce the risk of preeclampsia by as much as 71%.
Read more about this research below.

Preeclampsia is a complication of pregnancy associated with high blood pressure and excessive swelling of arms and legs. If untreated, the condition can progress to eclampsia, a condition characterized by seizures, coma, and possible death of the mother or child. In a recent study, lean women who used multivitamins before and during their pregnancies had their risk of preeclampsia reduced by 45-71 percent.

Research included 1,835 pregnant women enrolled in the Pregnancy Exposures and Preeclampsia Prevention Study. All women were at less than 16 weeks' gestation and were asked whether they regularly used multivitamins or prenatal vitamins in the past six months. Women that reported use of a multivitamin or prenatal during the previous six months had a 45 percent lower risk of preeclampsia than non-users. The reduction in risk was more significant among lean women. When lean women were analyzed separately, those who used multivitamins had a 71 percent lower risk of preeclampsia than nonusers.

These results suggest that regular use of a multivitamin supplement in the months before and during pregnancy may help prevent preeclampsia, particularly among lean women.

Bodnar LM, et al. Periconceptional multivitamin use reduces the risk of preeclampsia. 2006. Am J Epidemiol 164(5):470-7.

High Protein, Low-Glycemic Diets Better at Maintaining Weight Loss

New research shows that a low-glycemic diet relatively high in protein is more effective at weight maintenance than a low-protein, high-glycemic diet.

A recent study in the New England Journal of Medicine reports that a diet relatively high in protein and low in refined carbohydrates (low-glycemic) is more successful than other diets at maintaining weight loss.

Researchers enrolled overweight adults from eight European countries who had lost at least 8% of their initial body weight with a low-calorie diet. Participants were randomly assigned to one of five diets to prevent weight regain over a 26-week period: a low-protein and low-GI (glycemic index) diet, a low-protein and high-GI diet, a high-protein and low-GI diet, a high-protein and high-GI diet, or a control diet based on the current European dietary recommendations. The high protein diet provided 25 percent of calories in the form of protein, while the low protein diet consisted of 13 percent protein.

Five hundred forty-eight subjects completed six months on the assigned diets. In the analysis of participants who completed the study, only the low-protein/high-GI diet was associated with subsequent significant weight regain (1.67 kg, or 3.6 lbs) by the end of the dietary intervention. Weight regain was less in those who consumed high protein compared to low protein and in low-GI diets compared to high-GI diets. High-GI foods include white flour, white rice, and other refined carbohydrates.

This study shows that a modest increase in protein content and a modest reduction in glycemic index can lead to an improvement in compliance and maintenance of weight loss.

Larsen TM, et al. Diets with High or Low Protein Content and Glycemic Index for Weight-Loss Maintenance. 2010. N Engl J Med 363:2102-13.