Supplemental Vitamins During Breast Cancer Treatment May Reduce Mortality Risk

In a large population-based study of Chinese women with breast cancer, multivitamin use reduced the risk of mortality and the risk of cancer recurrence.

Nutritional supplement use during cancer treatment is currently controversial. Antioxidants may protect normal cells from oxidative damage that occurs during radiotherapy and certain chemotherapy regimens. However, the same mechanism could protect tumor cells and potentially reduce effectiveness of some cancer treatments. Recently, researchers evaluated vitamin supplement use during cancer treatment and in the first six months after breast cancer diagnosis, looking for correlations with total mortality and cancer recurrence.

A population-based prospective cohort study of 4,877 women diagnosed with invasive breast cancer was conducted between March of 2002 and April of 2006 in Shanghai, China. The women (aged 20-75) were interviewed approximately six months after diagnosis, then followed-up with later via in-person interviews.


During an average follow-up of 4.1 years, 444 deaths and 532 recurrences occurred. Vitamin use shortly after breast cancer diagnosis was associated with reduced risk of mortality and recurrence. Women who used nutritional supplements (vitamin E, vitamin C, multivitamins) had an 18% reduction in risk of mortality and a 22% reduced recurrence risk. The inverse association was found regardless of whether vitamin use was concurrent or non-concurrent with chemotherapy, but was only present among patients who did not receive radiotherapy.

Vitamin supplement use in the first six months after breast cancer diagnosis may be associated with reduced risk of mortality and recurrence. The results of this study do not support the current recommendation that all breast cancer patients should avoid use of vitamin supplements.

Nechuta S, et al. Vitamin supplement use during breast cancer treatment and survival: a prospective cohort study. Cancer Epidemiol Biomarkers Prev, 21 Dec 2010.

Healthy Eating Patterns Increase Survival Rates in Older Adults

A newly published study supports the idea that a relatively low-fat, plant-based diet increases quality of life and survival in older adults.

A report published in the January 2011 issue of the Journal of the American Dietetic Association concluded that eating healthy food really does increase survival in older adults.

Researchers analyzed data from 2,582 participants in The Health, Aging and Body Composition Study. Participants were American adults aged 70 to 79 upon enrollment. Dietary questionnaires completed during the second year after enrollment were used to identify 6 predominant dietary patterns: high-fat dairy products, meat, fried foods and alcohol, breakfast cereal, refined grains, sweets and desserts, and healthy foods. The healthy foods diet was characterized by a higher intake of low-fat dairy products, fruit, whole grains, poultry, fish and vegetables, and reduced consumption of meat, fried foods, sweets, high-calorie drinks and added fat.

During the follow-up period of up to 10 years, 739 deaths occurred in the study group. Those whose diets consisted of healthy food had a significantly lower risk of dying than those whose diets were dominated by high-fat dairy products (ice cream, cheese, whole milk), meat, fried foods and alcohol, sweets, and other desserts. Researchers found a 40 percent greater risk of dying among those who consumed relatively higher amounts of high-fat dairy products, and a 37 percent greater risk for those whose diets were characterized by a lot of sweets.

This study's findings are consistent with current guidelines to consume relatively high amounts of vegetables, fruit, whole grains, poultry, fish, and low-fat dairy products. Diets that follow this pattern appear to be associated with superior nutritional status, improved quality of life, and higher rates of survival in older adults.

Anderson AL, et al. Dietary Patterns and Survival of Older Adults. 2011. Journal of the American Dietetic Association 11(1):84-91.

Regular Exercise Reduces Risk of the Common Cold

New research shows a strong correlation between regular aerobic exercise and reduced risk of upper respiratory tract infections.


Upper Respiratory Tract Infections (URTI) can be caused by more than 200 different viruses, and it is estimated that the U.S. population suffers more than one billion colds a year (2-4 per average adult, 6-10 per average child). A number of lifestyle factors contribute to URTI risk, including poor nutrient status, lack of sleep, and stress. A new paper published in the British Journal of Sports Medicine adds exercise habits to the list of lifestyle factors affecting URTI risk.

1,023 subjects between 18 and 85 years of age were recruited for this study, with 1,002 individuals completing all study requirements. Subjects were selected from multiple BMI groups (roughly one-third were of normal weight, one-third were overweight, and one-third were obese) to ensure adequate representation. A comprehensive validated survey on lifestyle, diet, activity levels, stress, and URTI incidence and severity was completed by each study participant.

After controlling for potential cofounders, total days with URTI symptoms were 43-46% lower in the highest third of aerobic activity when compared to the lowest third, while URTI severity was reduced 32-41% for the high group. Low stress levels, high exercise frequency (≥5 days/week), and high fruit intake (≥3 servings/day) also correlated with reduced URTI incidence.

The exact mechanism by which aerobic exercise reduces URTI risk is still uncertain, although it appears to be a combination of factors, including transient increases of certain immune cell types, a reduction of stress hormones, and specialized benefits to key organs (particularly the lungs, which serve as a primary barrier against URTIs).

Nieman DC, Henson DA, Austin MD, Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. 2010. Br J Sports Med, ePub ahead of print. doi:10.1136/bjsm.2010.077875

High Vitamin B Levels Associated With Reduced Risk of Colorectal Cancer

In a recent population-based European study, individuals with higher vitamin B2 and B6 levels had significantly decreased risks of colorectal cancer.

New research reported in the October 2010 issue of Cancer Epidemiology, Biomarkers and Prevention shows a correlation between higher levels of vitamins B2 (riboflavin) and vitamin B6 and a reduced risk of developing colorectal cancer. B-vitamins are essential for metabolism and have been linked to a reduced risk of colorectal cancer in previous studies. Since associations with the B-vitamin folate have been studied most often, researchers in the current study focused on potential associations of other B vitamins (B2, B6, and B12) and colorectal cancer.

This European population-based study included subjects who were participants in the Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 1,365 adults diagnosed with colorectal cancer and 2,319 age and gender-matched control subjects. Blood samples were taken at enrollment and analyzed for vitamins B2, B6, and B12, as well as 8 variants of genes that relate to the function of these vitamins.

After an average follow-up of 3.6 years, individuals whose vitamin B6 levels were among the top 20 percent of participants had a 32 percent lower risk of developing colorectal cancer when compared to those whose levels were in the lowest 20 percent. Among those whose vitamin B2 levels were highest, the risk was 29 percent lower than those whose levels were lowest. There were no significant associations for vitamin B12 and colorectal cancer. Vitamin levels were lower in smokers compared to nonsmokers, and the benefits for vitamin B6 were stronger in males who consumed ≥30 g (one ounce) of alcohol per day.

This research is the first population-based study to indicate that vitamin B2 is inversely associated with colorectal cancer, and it supports previously suggested inverse associations of vitamin B6 with colorectal cancer.

Simone J.P.M. Eussen et al. Vitamins B2, B6, and B12, and Related Genetic Variants as Predictors of Colorectal Cancer Risk. Cancer Epidemiol Biomarkers Prev; 19(10); 2549–61.